Inter-protein residue covariation information unravels physically interacting protein dimers
نویسندگان
چکیده
منابع مشابه
Protein contacts, inter-residue interactions and side-chain modelling.
Three-dimensional structures of proteins are the support of their biological functions. Their folds are stabilized by contacts between residues. Inner protein contacts are generally described through direct atomic contacts, i.e. interactions between side-chain atoms, while contact prediction methods mainly used inter-Calpha distances. In this paper, we have analyzed the protein contacts on a re...
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. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xxiii CHAPTER 1. Overview . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 1.1 Experimental Methods to Identify Protein-Protein Interface Residues . . . . . . 2 1.2 Protein-Protein Interface Features . . . . . . . . . . . . . . . . . . . . . . . . . 4 1.3 Computational Methods to Predict Protein-Prote...
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Identifying the residues in a protein that are involved in protein-protein interaction and identifying the contact matrix for a pair of interacting proteins are two computational tasks at different levels of an in-depth analysis of protein-protein interaction. Various methods for solving these two problems have been reported in the literature. However, the interacting residue prediction and con...
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In view of the increasing interest both in inhibitors of protein-protein interactions and in protein drugs themselves, analysis of the three-dimensional structure of protein-protein complexes is assuming greater relevance in drug design. In the many cases where an experimental structure is not available, protein-protein docking becomes the method of choice for predicting the arrangement of the ...
متن کاملPredicting protein interface residues from residue conservation between interacting and non-interacting groups
It would be great if interface residues, which are responsible for protein-protein interactions, could be determined from the amino acid sequence. Sequence Harmony, Multi-RELIEF, SDPpred and GroupSim+ConsWin are used to predict interface residues from residue conservation between interacting and non-interacting groups. Therefore, a dataset based on Fungal Orthologous Groups is used. Different a...
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ژورنال
عنوان ژورنال: BMC Bioinformatics
سال: 2020
ISSN: 1471-2105
DOI: 10.1186/s12859-020-03930-7